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Worm:Win32/Gamarue.I has been described as a newly released worm infection which is generally diffused by a spammed email attachment such as Zip-archived extension. It is also prevalent to copy its vicious codes and registry files onto mobile devices like USB flash drives connected to user’s computer. Once being lurked and executed on target machine, the Worm:Win32/Gamarue.I virus will immediately replicate its negative files and values onto kernel system so that to mess up default system settings. In this case, the Worm:Win32/Gamarue.I virus could be loaded up automatically whenever PC starts. Meanwhile, the Worm:Win32/Gamarue.I malware may exploit found system loopholes in order to lead to additional infections, which may contain browser hijack virus, Trojan, fake antivirus applications to do further harm on compromised machine. Released by cyber criminals as a hack tool, the Worm:Win32/Gamarue.I virus could even record and reveal user’s keystrokes and confidential data stored on hard drive. Hence, it is urgent to clean up all components of Worm:Win32/Gamarue.I virus to avoid further damage.